Crow's Nest - Recent Research
This summer researchers from University of Pennsylvania made use of Crow's Nest Preserve to study Lyme disease and the bacterium (Borrelia burgdorferi) that causes it. Lyme disease is the most common vector-borne disease among humans in the U.S. Since it relies on ticks and alternate mammal hosts for its spread, a habitat for these animals such as that found at Crow's Nest makes a good study site.
Graduate student Parris Humphrey carried out the research as part of Dustin Brisson's lab at Penn with the help of Ian Hannigan, a first year Vet student, and undergraduate Eric Williams from Carleton College.
Different genotypes of bacterium infect separate species of mammal—mice, chipmunks, shrews, and squirrels—thereby avoiding competition. Humans are infected by only some of these genotypes.
To further knowledge of B. burgdorferi the Penn study has several goals:
1. Identify the different genotypes of the bacterium infecting each of the species in our region. This involves live-trapping small mammals and collecting engorged ticks from them before releasing them. (Amazingly, mice had anywhere from zero to 60 ticks on them apiece!)
2. Compare host reservoir species in the mid-Atlantic with those studied in other regions. This requires collecting data on rates of transmission of each genotype to feeding ticks, tick burdens, animal densities, and the frequency of each genotype in host-seeking ticks.
3. Build predictive models for Lyme disease risk using variables such as forest type, forest fragment size, and climate.
4. Eventually, field test a vaccine for small mammals that blocks transmission of the Lyme disease bacterium between mammal hosts and feeding ticks.
In the photo above Parris is sorting collected ticks; he will be spending the fall in the lab analyzing their bacteria. We are happy that University of Pennsylvania was able to use Crow's Nest for this research.










